Microexons: discovery, regulation, and function
نویسندگان
چکیده
منابع مشابه
Microexons--tiny but mighty.
The landscape of alternative splicing is only beginning to unravel, and the functional consequences are often unclear. Two articles in Cell and Genome Research focus on a set of largely ignored yet highly conserved exons, microexons. These appear strongly regulated by RNA-binding proteins (RBPs) and functionally modulate protein–protein interactions with strong evidence for deregulation in auti...
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Microexons are frequently underestimated in transcriptome analyses. Two studies published in Cell and Genome Research now independently report the identification of hundreds of microexons. Alternative splicing of some microexons is regulated by neuronal-specific RNA-binding proteins and modifies the function of proteins involved in neurogenesis, with misregulation linked to autism.
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: RNA
سال: 2017
ISSN: 1757-7004
DOI: 10.1002/wrna.1418